Deep-brain stimulation
STN/GPi DBS implantation, patient selection and long-term outcomes on motor symptoms and quality of life.
State of the art
No update yet for Deep-brain stimulation. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization
The article frames DBS optimisation as having two separable dimensions — spatial (which contact, which direction, what field shape) and temporal (when and how much to stimulate) — and argues that rigorous spatial programming using directional leads and beta-guided or image-guided contact selection is a necessary foundation before adding adaptive capability. This sequencing argument is directly relevant to patients being assessed for conventional DBS or considering a system upgrade. -
Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control
This within-subject FDG-PET study of 14 thalamic DBS patients shows that local metabolic changes at the stimulation site do not predict tremor improvement, but how well the individual's brain-wide metabolic response aligns with a published tremor treatment network does (R²=0.593, p=0.007). The finding supports network-engagement — rather than local suppression — as the mechanism behind effective DBS, and points toward connectome-based electrode targeting and programming optimisation as a clinically actionable next step.