Caffeine
Caffeine the compound — A2A-receptor antagonism, motor symptoms, dyskinesia risk and neuroprotection signals.
State of the art
No update yet for Caffeine. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Exercise and smoking: health rivals revealing shared protective mechanisms in Parkinson’s?
The paper's framework of identifying shared neuroprotective mechanisms from lifestyle exposures (exercise, tobacco) parallels and contextualises prior work on caffeine's A2A-receptor-mediated protection, reinforcing the concept that multiple modifiable factors may converge on common disease-relevant pathways. -
Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
The study's discussion notes published evidence that caffeine intake modifies PD risk specifically among LRRK2 variant carriers in Asian populations, flagging genotype-stratified pharmacoepidemiology of caffeine as a future research direction for this high-risk subgroup. -
Café pode ajudar cognição em pacientes com Parkinson; entenda - diariodopara.com.br
An observational study of 149 early-diagnosed Parkinson's patients (published April 2026, Parkinsonism & Related Disorders) found that regular coffee drinkers outperformed non-drinkers on executive-function tests — most notably the Go-No-Go Test, which measures attention and impulse inhibition. The result is an association only; no causal claim can be made, and the authors do not recommend increasing caffeine intake.