LRRK2 Caffeine
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Caffeine intake may specifically modify PD risk in East Asian carriers of LRRK2 risk variants, supporting genotype-stratified investigation of caffeine as a risk modifier.
Caffeine intake may modify PD risk among LRRK2 variant carriers in Asian populations, and first-in-class type II kinase inhibitors that stabilize the inactive LRRK2 conformation have recently been reported, highlighting opportunities for pharmacogenomic stratification and targeted prevention.