Synaptic & vesicular dysfunction
Synaptic vesicle cycling, VPS35-linked endosomal trafficking and SV2C / VMAT2 dysfunction at the synapse.
State of the art
No update yet for Synaptic & vesicular dysfunction. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Region-specific cortico-striatal transcriptomic remodeling following early postnatal dopaminergic disturbance
Prefrontal-cortex-specific co-expression modules following early dopamine loss were linked to trans-synaptic signalling and chemical synaptic transmission ("darkred" and "grey60" modules); in the striatum, gene changes were enriched in excitatory neuronal signatures and extracellular matrix organisation — a scaffold critical for synaptic stabilisation. This region-specific remodelling of synaptic gene networks by dopaminergic disturbance maps a circuit-level vulnerability relevant to PD.