Orthostatic hypotension
Postural blood-pressure drops, droxidopa, midodrine and non-pharmacological strategies.
State of the art
No update yet for Orthostatic hypotension. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson’s disease and multiple system atrophy
This 20-person randomised trial (the Heads-Up trial) is the first prospective study to test graduated head-up tilt sleeping (HUTS) specifically in PD and MSA patients who have both orthostatic hypotension and supine hypertension simultaneously — the hardest-to-treat blood-pressure pattern. At bed angles of 6°–12°, HUTS improved the blood-pressure drop on standing and normalised the 24-hour pressure profile without adding medication; 6° was fully tolerated, while 18° was only sustained by 60% of participants.