VPS35 & other monogenic
VPS35, DJ-1 (PARK7), ATP13A2, DNAJC6, CHCHD2 and other rarer monogenic forms of PD.
State of the art
No update yet for VPS35 & other monogenic. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
An intronic protective variant in VPS13C (rs12900645; OR 0.82) was identified as the lead signal within a previously described protective haplotype region, with the authors noting VPS13C encodes a lipid-transfer protein involved in lysosomal–mitochondrial homeostasis — though the signal requires replication.