SNCA
Alpha-synuclein gene multiplications and missense variants in familial PD.
State of the art
No update yet for SNCA. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
The study identifies an East Asian–enriched SNCA risk haplotype centred on intron-4 variants (rs5860181, rs3775427) that is partially independent of the European rs356182 signal, and finds a possible secondary 5′ UTR signal (rs3756059) previously linked to REM sleep behaviour disorder — adding population-specific resolution to SNCA risk architecture.