Polygenic risk & GWAS
GWAS loci, polygenic risk scores and idiopathic PD heritability estimates.
State of the art
No update yet for Polygenic risk & GWAS. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan
This first Taiwan-wide PD GWAS shows that a European-derived 90-variant polygenic risk score achieves only modest discrimination (AUC 0.59) in Taiwanese patients, while a compact 16-variant panel tailored to East Asian and Taiwan-specific loci reaches AUC 0.62 — supporting the need for ancestry-matched risk tools.