Iron & ferroptosis
Iron accumulation in nigral neurons, lipid peroxidation and ferroptotic cell death — the rationale for iron chelation.
State of the art
No update yet for Iron & ferroptosis. An update is a standalone state-of-the-art for the topic — what someone with Parkinson's needs to know about where this approach stands today.
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Levodopa increases substantia nigra iron: implications for Parkinson's disease
This preprint adds to evidence that levodopa treatment itself may increase iron accumulation specifically in the substantia nigra — not just PD pathology alone — suggesting the drug could contribute to the oxidative and ferroptotic stress it is meant to work around. -
Superior dorsal nigral hyperintensity depiction at 7 T MRI using CLEAR-DESS improves diagnosis performance of Parkinson’s disease
The head-to-head comparison between iron-sensitive SWI and the iron-suppressing CLEAR-DESS sequence at 7T MRI provides indirect in-vivo evidence that iron accumulation in the substantia nigra, while detectable, is not the optimal contrast mechanism for diagnosing PD: neuromelanin/free-water contrast captured by CLEAR-DESS gave markedly higher diagnostic accuracy.