Dementia & MCI Genetics
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APOE ε4 and MAPT H1 variants increase Alzheimer-type co-pathology burden in PD patients, substantially raising dementia risk above that from Lewy body pathology alone.
Shared genetic risk factors — particularly APOE ε4, a major Alzheimer's disease susceptibility allele, and the MAPT locus associated with both AD and PD — increase the accumulation of tau and amyloid co-pathology in PD brains, linking an individual's genetics to their probability of developing dementia.