Picks (written 2026-05-30)
Three of today's research picks converge on the same underlying problem: getting dopamine to the right place at the right time. Gene therapy aims to rebuild the brain's own production; the levodopa pharmacodynamics piece maps where oral treatment silently falls short; adaptive DBS research asks how stimulation can be shaped to fill those gaps. Together they sketch a progression from today's medications toward more precise, individualized treatment.
Latest research
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Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease summary
Human safety and early effect data from dopamine gene therapy Phase 1/2 trial, OXB-102.
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The Dark Matter of Levodopa Pharmacodynamics
Maps unexplained gaps in levodopa response; directly relevant to medication timing and fluctuations.
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The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization summary
Positions adaptive DBS: optimize electrode placement spatially before tuning stimulation timing.
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Superior dorsal nigral hyperintensity depiction at 7 T MRI using CLEAR-DESS improves diagnosis performance of Parkinson’s disease summary
7T MRI with CLEAR-DESS raises nigral diagnostic accuracy at specialist imaging centres.
News, foundations & community
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Biogen and Denali halt BIIB122 trial for idiopathic Parkinson’s
Negative result: BIIB122 failed to slow idiopathic PD progression; major Biogen/Denali trial halted.
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Patient account of focused ultrasound relieving severe, previously refractory PD pain.
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Parkinson e caldo: le alte temperature possono peggiorare i sintomi? - Pazienti.it
Practical summer warning: high temperatures can worsen motor and non-motor PD symptoms.