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Picks (written 2026-05-16)

by xavier.grehant

Latest research

  1. Diagnostic, Prognostic Value, and Pathological Associations of Levodopa Responsiveness in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy Annals of Neurology (Wiley) · 2026-05-15

    Large cohort quantifies what levodopa response predicts across PD, MSA, and PSP prognosis.

  2. Addressing Care Partner Burden from the Underrecognition of Iatrogenic Sexual Behavior Changes in Parkinson's Disease summary Movement Disorders (Wiley) · 2026-05-11

    Clinical review: medication-induced sexual behavior changes missed by most care teams.

  3. Daily‐Life, Sensor‐Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease summary Annals of Neurology (Wiley) · 2026-05-13

    Wrist-worn sensors detect early tremor progression reliably without additional clinic visits.

  4. Multi-locus genetic dosage shapes cognitive disease progression in Parkinson’s patients: 15-year meta-analysis of 24 cohorts summary Parkinson's Disease (Nature) · 2026-05-14

    15-year, 24-cohort meta-analysis links genetic load to rate of cognitive decline.

  5. Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson’s disease summary Parkinson's Disease (Nature) · 2026-05-12

    Non-invasive motor cortex stimulation partially reverses bradykinesia in human participants.

  6. Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study summary Parkinson's Disease (Nature) · 2026-05-15

    Longitudinal community study: loneliness independently worsens motor and cognitive scores.

  7. Aperiodic subthalamic activity underlies sleep-wake modulation of beta power during conventional and adaptive deep brain stimulation in Parkinson's disease medRxiv — Neurology preprints · 2026-05-13

    Sleep-wake beta signal shifts matter for adaptive DBS calibration in current patients.

News, foundations & community

  1. Phase 3 trial of solengepras for Parkinson’s disease now fully enrolled summary Parkinson News Today · 2026-05-15

    Phase 3 non-dopaminergic solengepras trial fully enrolled; efficacy results now anticipated.

  2. Vyalev eases motor, nonmotor symptoms in advanced Parkinson’s summary Parkinson News Today · 2026-05-14

    Vyalev subcutaneous infusion cuts off time and nonmotor burden in advanced PD.

  3. New, free Parkinson’s card game aims to help couples rekindle intimacy Parkinson News Today · 2026-05-13

    Free APDA card game addresses intimacy challenges couples can request today.

  4. Prebiotics balance gut bacteria and show results in Parkinson’s blood summary Parkinson News Today · 2026-05-07

    Prebiotic restores gut bacteria; blood test now tracks gut-brain response over time.

  5. Parkinson’s and menopause Parkinson News Today · 2026-05-07

    Practical guide to overlapping symptoms when Parkinson's and menopause coincide.

  6. Holding on to my independence with a tailored morning routine Parkinson News Today · 2026-05-11

    Patient shares specific bathroom and morning adaptations preserving day-to-day independence.

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