Dementia & MCI immune-risk-factors
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Higher pulse pressure (per 10 mmHg) independently predicted incident dementia with a 5.4% higher hazard, driven mainly by Alzheimer's disease; no significant association was found for dementia with Lewy bodies.
Each 10mm Hg increase in pulse pressure was associated with a 5.4% higher risk of dementia (95% confidence interval on hazard ratio: 1.036 to 1.071), even after adjustment for age, mean arterial pressure and other established dementia risk factors. The effects were disproportionately stronger for Alzheimer's disease and vascular dementia, with no clear evidence for increased risk for dementia with Lewy bodies or frontotemporal dementia.