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Picks (written 2026-05-19)

by xavier.grehant

Three of today's research picks converge on individual prognosis: levodopa response, the alpha-synuclein seed assay, and multi-locus genetic scores are building a toolkit to tell each patient where their disease is headed — not just where Parkinson's goes on average. For patients and families navigating diagnosis or worried about cognitive trajectory, these tools are moving from research instruments toward clinical questions worth raising at the next appointment.

Latest research

  1. Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson’s disease and multiple system atrophy summary npj Parkinson's Disease (Nature) · 2026-05-16

    Clinical data on head-up tilt sleeping tolerability and autonomic benefit in PD and MSA.

  2. Diagnostic, Prognostic Value, and Pathological Associations of Levodopa Responsiveness in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy Annals of Neurology (Wiley) · 2026-05-15

    Levodopa response mapped to underlying pathology and prognosis across PD, MSA, and PSP.

  3. Multi-locus genetic dosage shapes cognitive disease progression in Parkinson’s patients: 15-year meta-analysis of 24 cohorts summary npj Parkinson's Disease (Nature) · 2026-05-14

    15-year, 24-cohort analysis links specific gene combinations to rate of cognitive decline.

  4. The α-Synuclein seeding assay discriminates between LRRK2 p.Gly2019Ser variant carriers with and without Parkinson's disease. medRxiv — Neurology preprints · 2026-05-17

    Alpha-synuclein seed assay identifies which LRRK2 carriers already have PD pathology.

  5. Loneliness predicts worse Parkinsonism: a longitudinal, community-based, clinical-pathological study summary npj Parkinson's Disease (Nature) · 2026-05-15

    Longitudinal clinical-pathological study ties social isolation to faster parkinsonism progression.

News, foundations & community

  1. Cellular Intelligence acquires global rights to STEM-PD program summary Parkinson News Today · 2026-05-18

    Novo Nordisk's allogeneic STEM-PD cell therapy program acquired, keeping it in active development.

  2. 'Garbage collectors' of the brain grind to a halt in fatal multiple system atrophy summary Medical Xpress — Neurology · 2026-05-18

    MSA's lysosomal clearing system identified as failing, opening concrete new treatment targets.

  3. Una tecnología para tratar el párkinson elimina el dolor a Inma, paciente con la "enfermedad del suicidio": "Es un cambio descomunal" - La Opinión de Málaga summary Google News — «párkinson» (es) · 2026-05-18

    Patient describes dramatic pain relief after a Parkinson's neuromodulation treatment.

  4. Démence à corps de Lewy : voici pourquoi elle est confondue avec Parkinson et Alzheimer (et ce que ça change) - Cap Retraite summary Google Actualités — « maladie de Parkinson » · 2026-05-18

    Plain-language explainer on why Lewy body dementia is misdiagnosed as Parkinson's or Alzheimer's.

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