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Picks (written 2026-06-02)

by xag

Two of today's research picks put pressure on levodopa's long-term profile: one finding suggests it may raise iron levels in the substantia nigra, while another maps how its neuropsychiatric effects run on a different clock than its motor effects. Neither is a reason to stop medication, but both give patients and neurologists more precise questions to bring to their next appointment.

Latest research

  1. Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease summary Movement Disorders (Wiley) · 2026-05-28

    Phase 1/2 human safety data on dopamine gene therapy OXB-102/Axo-Lenti-PD.

  2. Levodopa increases substantia nigra iron: implications for Parkinson's disease summary bioRxiv — Neuroscience preprints · 2026-06-01

    Levodopa may raise substantia nigra iron, raising ferroptosis concern for long-term users.

  3. Distinct temporal dynamics of motor and neuropsychiatric responses to levodopa in Parkinson's disease medRxiv — Neurology preprints · 2026-06-01

    Neuropsychiatric fluctuations follow distinct levodopa timing from motor ones — actionable for dose discussions.

  4. Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease Annals of Neurology (Wiley) · 2026-05-28

    Gut virome signature identified in prodromal and confirmed Parkinson's, advancing biomarker work.

  5. Dopamine–endocannabinoid crosstalk drives exercise-induced bidirectional plasticity in Parkinson’s disease npj Parkinson's Disease (Nature) · 2026-06-01

    Mechanism explaining why exercise improves motor plasticity — supports structured exercise prescriptions.

News, foundations & community

  1. Parkinson’s Speech Exercises: JUNE CHALLENGE Parkinson Voice Project · 2026-06-01

    June speech exercise challenge from Parkinson Voice Project — ready to start today.

  2. Anvisa aprova novo medicamento para tratamento da doença de Parkinson avançada - Ceará Agora Google Notícias — "doença de Parkinson" (pt-BR) · 2026-06-01

    Brazil's Anvisa approves new advanced-Parkinson's therapy — regulatory milestone for affected patients.

  3. How does exercise and Parkinson's change how many calories I need a day? #shorts#parkinson#exercise Davis Phinney Foundation · 2026-06-01

    Practical calorie guidance for patients managing exercise intensity with Parkinson's.

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